Effects of porosity on drug release kinetics of swellable and erodible porous pharmaceutical solid dosage forms fabricated by hot melt droplet deposition 3D printing

3D Printing by Fused Deposition Modeling of Capsular Devices for Oral Pulsatile Release Based on Swellable/Erodible Polymers

Swellable/Erodible Polymers A. Melocchi , F. Parietti , F. Casati , A. Maroni , A. Gazzaniga , L. Zema 1 1 Universita Degli Studi di Milano, 2 Massachusetts Institute of Technology Purpose To prepare swellable/erodible capsular devices for oral pulsatile release via 3D printing by Fused Deposition Modeling (FDM), starting from in-house produced filaments based on hydroxypropyl cellulose (HPC), ...

Stereolithographic (SLA) 3D printing of oral modified-release dosage forms.

The aim of this work was to evaluate the suitability of stereolithography (SLA) to fabricate drug-loaded tablets with modified-release characteristics. The SLA printer creates solid objects by using a laser beam to photopolymerise monomers. In this work polyethylene glycol diacrylate (PEGDA) was used as a monomer and diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide was used as a photo-initiator....

An artificial blood vessel fabricated by 3D printing for pharmaceutical application

Objective(s): Cardiovascular diseases (CVDs) are the leading cause of mortality in the elderly. A common medical procedure for the treatment of CVDs is the replacement of the blocked or narrowed arteries, which is currently the optimal vascular transplant associated with autograft transplantation. In general, the saphenous veins and radial arteries in the mammary gland are considered to be the ...

Development of Continuous Manufacturing of Filaments for Pharmaceutical 3D Print Dosage Forms Utilizing Hot Melt Extrusion Technology

Lubricants in Pharmaceutical Solid Dosage Forms

Lubrication plays a key role in successful manufacturing of pharmaceutical solid dosage forms; lubricants are essential ingredients in robust formulations to achieve this. Although many failures in pharmaceutical manufacturing operations are caused by issues related to lubrication, in general, lubricants do not gain adequate attention in the development of pharmaceutical formulations. In this p...